Chloroquine and Remdesevir for prophylaxis

Apr 19, 2020COVID Literature Appraisal, Prevention: Drugs

In vitro inhibition of COVID-19 by chloroquine

In Vero E6 cell line, chloroquine seems to be promising in preventing entry into the cell as well as post entry inhibition. Efficacy and safety needs to be confirmed in humans by a randomized controlled study.

Wang, M. et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30, 269–271 (2020)

Chloroquine for influenza prevention

The absence of efficacy of chloroquine in preventing influenza, may not apply to its use in other indications such as COVID19 or prevent us from trying it in human trials to prevent the infection.

Paton, N. I. et al. Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial. Lancet Infect. Dis. 11, 677–683 (2011)

Prevention-drugs-HCQS and Remdecivir