Pooled sample testing to detect community transmission of SARS‐CoV‐2

Apr 29, 2020COVID Literature Appraisal, Indications and tests for diagnosis

The strategy of sample pooling has earlier been used for community monitoring of trachoma. For diagnosis of SARS-CoV infection it may facilitate rational utilisation of resources; and is useful in areas with low prevalence of the disease. The ICMR conducted a feasibility study in KGMU Lucknow by pooling five samples; and has recommended its use only in areas with a low prevalence of the disease i.e. <2% from the existing data. Pooling is not advised in areas with positivity rates of >5%. (ICMR advisory dated 13.04.2020). However, pooled sample diagnosis can provide an effective strategy to track or monitor the spread or resurgence of an infection within a population.

Article: Hogan CA, Sahoo MK and Pinsky B. Sample pooling as a strategy to detect community transmission of SARS-CoV-2. JAMA April 2020. doi. 10.1001/jama.2020.544  [LINK]


Indications and tests-Pooled Samples